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Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects

N

National Center for Research Resources (NCRR)

Status

Completed

Conditions

Heart Defects, Congenital
Tetralogy of Fallot
Pulmonary Valve Stenosis
Conotruncal Cardiac Defects
Hypoparathyroidism
Pulmonary Atresia

Treatments

Drug: sodium citrate
Drug: calcium gluconate

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT00004361
199/11936
NU-553

Details and patient eligibility

About

OBJECTIVES: I. Identify latent hypoparathyroidism in normocalcemic adult survivors with repaired conotruncal cardiac defects, by evaluating parathyroid gland secretory function after induced hypocalcemia.

II. Determine the relationship of parathyroid hormone secretion to microdeletions in the same region of chromosome 22q11 as found in patients with DiGeorge anomaly.

Full description

PROTOCOL OUTLINE:

Patients are given sodium citrate over a 2 hour infusion on day 1. Blood is drawn at times -30, -15, 0, and every 10 minutes thereafter during the infusion. On day 2, patients are given calcium gluconate over a 2 hour infusion. Blood is drawn at times -30, -15, 0, and every 10 minutes thereafter during the infusion.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

  • Diagnostically shown repaired or palliated conotruncal cardiac defects, including tetralogy of Fallot with pulmonary stenosis or pulmonary atresia, truncus arteriosus, or interrupted aortic arch type B

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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