Study of the Relationship Between the Pharmacokinetics (PK) and Pharmacodynamics of Venetoclax in Patients With Acute Myeloblastic Leukemia (EUREKA-VEN)

Léon Bérard Center

Status

Enrolling

Conditions

Acute Myeloid Leukemia

Treatments

Other: Pharmacokinetic dosages of venetoclax

Study type

Interventional

Funder types

Other

Identifiers

NCT07243483

ET24-223

Details and patient eligibility

About

This is a prospective, multicenter, clinical-biological cohort study. Its objective is to assess the pharmacokinetics-pharmacodynamics (PK-PD) of venetoclax (VEN) in patients with Acute Myeloid Leukemia (AML).

This study involves only minimal risks and constraints related to the collection of biological samples (blood samples for PK testing) and the collection of clinical data. Therapeutic management of patients participating in this study is not changed. A total of 100 patients will be included in the study over a 12-month period. A maximum of 21 additional samples are planned, with a maximum of 12 mL of blood per sampling day (4 mL at each sampling time) for PK dosing of venetoclax.

Enrollment

100 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male or female patient aged of at least 18 years on day of signing informed consent
Patient with histologically-confirmed diagnosis of Acute Myeloblactic Leukaemia according to classification ELN 2022 (European Leukemia Net 2022)
Patient who has to initiate treatment venetoclax-azacitidine as first line. Note : triple associations with targeted therapy are not authorized
Patient should understand, sign, and date the written voluntary informed consent form prior to any protocol-specific procedures performed.
Patient must be affiliated or benificiary of a social security system.

Exclusion criteria

Patient with acute promyelocytic leukemia (APL, AML3)
Patient with AML eligible to intensive chemotherapy
Patient previously treaed with venetoclax and/or azacitidine
Patient participating to another clinical trial with a medicinal product
Any condition that contraindicates blood sampling procedures required by the protocol
Any psychological, family, geographical, or social situation that, according to investigator's judgment, could potentially prevent the signing of an informed consent form and/or woulld likely interfere compliance with study procedures.
Patient under curatorship, guardianship or judicial protection
Pregnant or breast-feeding female patient.