Study of the Reproducibility of the French Version of the Modified SMAFRS Scale (mSMAFRS-F)

Institut de Myologie, France

Status: Enrolling

Conditions: SMA

Treatments: Other: Questionnaire and Physical Exam

Study type: Observational

Funder types: Other

Identifiers

NCT07321990

mSMAFRS-F

Details and patient eligibility

About

The goal of this observational study is to evaluate the test-retest reliability of the French version of the mSMAFRS in adult patients with SMA. The main question[s] is to answer if:

• ICC is a good estimate of test-retest reliability?
• mSMAFRS-F correlate with other outcome measures?

Participants will simply answer a french version of the SMA-FRS questionnaire during their routine follow-up visit then again fifteen days later.

Full description

The modified SMAFRS is a patient-reported outcome measure (PROM) designed to assess the level of independence in ten activities of daily living (ADLs) within one's own environment for individuals with SMA. Activities include eating, dressing, bathing, toileting, grooming, turning in bed/adjusting bedclothes, transfers, walking, climbing stairs, and respiratory status. Each item is scored from 0 (fully dependent) to 5 (fully independent) by the patient or caregiver, maximum score of 40. The mSMAFRS has been used in several therapeutic and 9/21 2025-A00536-43_PROTOCOLE_V1.2_20250707_mSMAFRS-F observational studies. Feasibility, test-retest reliability, construct & content validity has been demonstrated for the English version. However currently no French version exists. Therefore, each clinician or health professional translates the items themselves during consultation with patients. This has consequences for inter-rater reliability as translations are likely to differ from one clinician to another and for intra-rater reliability as translations may differ at each visit. Therefore, successive evaluations are compromised. It is essential that an official French version exists for both clinical and research use. The added benefit of the mSMAFRS to other functional scales (e.g., MFM) is its specificity in SMA and its simplicity to perform as it is patient-reported and not observer-rated. It is useful and relevant for both ambulant and non-ambulant individuals and it includes a respiratory item which is lacking in the other functional scales.

Enrollment: 60 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Genetically confirmed SMA
• Able to comply with all protocol requirements (no significant cognitive impairment)
• French-speaking
• Affiliated or beneficiary of a social security scheme

Exclusion criteria

• Persons subject to a legal protection measure
• Subjects unable to complete the French version of the questionnaire mSMAFRS-Fbecause of lack of French fluency
• Subjects unable to complete the French version of the questionnaire mSMAFRS-Fbecause of cognitive impairment
• Inability to comply with protocol requirements
• Any medical and social conditions that could interfere with the study under theappreciation of the medical coordinator

Trial design

60 participants in 1 patient group

Treated patients

Treatment:

Other: Questionnaire and Physical Exam