Study of the Vascular Disrupting Agent NPI-2358 in Patients With Advanced Solid Tumors or Lymphoma

Nereus Pharmaceuticals

Status and phase

Completed

Phase 1

Conditions

Cancer

Treatments

Drug: NPI-2358

Study type

Interventional

Funder types

Industry

Identifiers

NCT00322608

NPI-2358-100

Details and patient eligibility

About

This is a Phase 1 clinical trial examining the safety, pharmacokinetics and pharmacodynamics of escalating doses of the vascular disrupting agent NPI-2358 in patients with refractory solid tumors or lymphoma. The formation of new blood vessels (angiogenesis) is an important component of tumor growth and vascular disrupting agents are intended to target the differences between these tumor blood vessels and the blood vessels in normal tissues. NPI-2358 has also been seen to directly affect tumor cells.

Enrollment

35 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

ECOG performance status ≤ 2
Pathologically or histologically confirmed solid tumor malignancy
Patients must not be candidates for regimens known to provide clinical benefit.
All adverse events of any prior chemotherapy, surgery, or radiotherapy, must have resolved to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) (v. 3.0) Grade ≤ 2, except for neurological toxicity that must have resolved to Grade ≤ 1.
Adequate bone marrow reserve, hepatic and renal function
Signed informed consent

Exclusion criteria

Administration of chemotherapy, biological, immunotherapy or investigational agent (therapeutic or diagnostic) within 21 days prior to receipt of study medication (6 weeks for nitrosoureas or mitomycin C; 12 weeks for radioimmunotherapy). Major surgery, other than diagnostic surgery, within 6 weeks before first study drug administration. Radiotherapy within 4 weeks (some types of radiation therapy are excluded regardless of interval since treatment).
Significant cardiac history or findings
Underlying conditions or medications associated with bleeding diathesis
Disorders associated with significant vascular pathology
Lung cancer with central chest tumors
Prior treatment with vascular disruptive agents
Seizure disorder requiring anticonvulsant therapy; prior transient ischemic attack or cerebrovascular accident
Brain metastases
Severe chronic obstructive pulmonary disease (COPD) with hypoxemia
Active uncontrolled bacterial, viral, or fungal infection, requiring systemic therapy
Known infection with human immunodeficiency virus (HIV), active hepatitis A, B, or C
Patients with a prior hypersensitivity reaction to any product containing Solutol and/or propylene glycol
Pregnant or breast-feeding women. Female patients must be postmenopausal, surgically sterile or they must agree to use acceptable methods of birth control. Female patients with childbearing potential must have a negative serum pregnancy test. Male patients must be surgically sterile or agree to use an acceptable method of contraception.
Concurrent, active second malignancy for which the patient is receiving therapy, excluding basal cell carcinoma of the skin or carcinoma in situ of the cervix