Study of Tigecycline Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy(CRRT)

Zhujiang Hospital

Status: Unknown

Conditions: Critically Ill; Bacterial Infection

Treatments: Drug: Tigecycline

Study type: Observational

Funder types: Other

Identifiers

NCT02931526

LCYJ1

Details and patient eligibility

About

The aim of this study is to determine the Pharmacokinetics/Pharmacodynamics(PK/PD) of tigecycline in critical ill patients undergoing continuous renal replacement therapy（CRRT）and examine whether the dosage needs adjustment.

The study will observe two groups of patients respectively and compare the difference between them. Patients who need to receive CRRT when treat with high-dose tigecycline will be collected in Group CRRT. Patients who treat with high-dose tigecycline only will be collected in Group non-CRRT.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18-75 years,hospitalized ICU patients, male or female;
• having definitive diagnosis to treat with tigecycline for bacterial infection;
• receiving CRRT with renal insufficiency or not receiving CRRT with normal renal function.

Exclusion criteria

• Patients with Child-Pugh C cirrhosis;
• Allergic to tetracycline or tigecycline;
• Patients received CRRT for < 3 days or treated with tigecycline < 3 days;
• Patients who are pregnant.

Trial design

20 participants in 2 patient groups

Group CRRT

Description:

Patients who need to treat with tigecycline for bacterial infection, have renal insufficiency and have to treat with CRRT

Treatment:

Drug: Tigecycline

Group non-CRRT

Description:

Patients who need to treat with tigecycline for bacterial infection, have normal renal function in ICU and have no need to treat with CRRT

Treatment:

Drug: Tigecycline