Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer

Alliance for Clinical Trials in Oncology

Status: Completed

Conditions: Lung Cancer

Treatments: Other: laboratory biomarker analysis; Other: medical chart review; Genetic: DNA analysis; Genetic: gene expression analysis; Genetic: DNA methylation analysis; Genetic: RNA analysis; Genetic: polymorphism analysis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01414595

CALGB-151107

CDR0000706375 (Registry Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.

Full description

OBJECTIVES:

• To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens.
• To identify and characterize structural variations in the genomes of NSCLC specimens.
• To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation.

OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.

Enrollment: 248 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Patient must have been registered to CALGB 140202.
• Tumor histology should be either primary adenocarcinoma or squamous cell carcinoma of the lung.
• Patients are eligible for this study if their samples from CALGB 140202 are available.
• All living patients must sign the CALGB 151107 consent form to be eligible for this trial.

Trial design

248 participants in 1 patient group

Group 1

Description:

CALGB 140202 outlines the standard procedures for sample procurement. Samples to be used for this project have already been obtained and are currently banked at the CALGB Pathology Coordinating Office (PCO) and the Lung Cancer Tissue Bank at Brigham and Women's Hospital.

Treatment:

Other: medical chart review

Other: laboratory biomarker analysis

Genetic: DNA analysis

Genetic: RNA analysis

Genetic: polymorphism analysis

Genetic: gene expression analysis

Genetic: DNA methylation analysis