Study of Tocotrienol Absorption and Distribution Under Different Fat Status

Malaysia Palm Oil Board

Status: Completed

Conditions: Absorption

Treatments: Dietary Supplement: Tocotrienol

Study type: Interventional

Funder types: Other

Identifiers

NCT01185769

PD141/09

Details and patient eligibility

About

Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols

Full description

There is a possibility that the absorption and distribution of tocotrienols may occur differently compared with tocopherols, especially under different fat status

Enrollment: 10 patients

Sex: Male

Ages: 22 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male aged 22-25
• body mass index 18.5 < X < 30 kg/m2
• plasma cholesterol < 5.2 mmol/L,
• TAG < 1.7 mmol/L

Exclusion criteria

• history of cardiovascular disease
• diabetic
• body mass index < 18.5 or > 30 kg/m2
• plasma cholesterol > 5.2 mmol/L,
• TAG > 1.7 mmol/L
• hypertension
• currently taking Vitamin E supplement
• current use of medication
• smoking.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 2 patient groups

High fat

Experimental group

Description:

500 mg of tocotrienol will be administered at single dose after consumption of high fat diet

Treatment:

Dietary Supplement: Tocotrienol

Dietary Supplement: Tocotrienol

Low fat

Experimental group

Description:

500 mg of tocotrienol will be administered at single dose after consumption of low fat diet

Treatment:

Dietary Supplement: Tocotrienol

Dietary Supplement: Tocotrienol