Study of Tomotherapy HD in Medulloblastoma

Shanghai Jiao Tong University

Status: Unknown

Conditions: Medulloblastoma

Treatments: Device: 3DCRT; Device: Tomotherapy HD

Study type: Interventional

Funder types: Other

Identifiers

NCT03675230

XH-18-012

Details and patient eligibility

About

The aim of the study was to improve local control and long-term survival in children with medulloblastoma, reduce the side effects of treatment and improve quality of life.

Full description

The technical advantages of Tomotherapy HD in the radiotherapy of children medulloblastoma (advantages in clinical operation and physics) were transformed into clinical advantages, and the possible mechanisms were explored.

Enrollment: 220 estimated patients

Sex: All

Ages: 3 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patient was diagnosed as myeloblastoma by surgical pathology with definite pathological classification. MRI of the head and spinal cord before and after operation, with definite staging; Radiotherapy was performed within 28 days after surgery.

Exclusion criteria

• Previous radiotherapy in the whole brain, whole spinal cord or primary focus; Postoperative radiotherapy for more than 28 days.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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220 participants in 2 patient groups

3DCRT

Active Comparator group

Description:

This arm will be planned by 3DCRT to the treatment of the Medulloblastoma

Treatment:

Device: 3DCRT

Tomotherapy HD，TOMO

Experimental group

Description:

This arm will be planned by TOMO to the treatment of the Medulloblastoma

Treatment:

Device: Tomotherapy HD