Study of Virus-specific Lymphocytic Cell Populations in Non-invasive Nasal Mucosa Samples of MIS-C Patients

Medical University of Warsaw

Status: Enrolling

Conditions: COVID-19; MIS-C Associated With COVID-19

Study type: Observational

Funder types: Other

Identifiers

NCT05560906

NAWA015

Details and patient eligibility

About

The aim of the study is to make an accurate assessment of immune cells obtained from nasal mucosa and peripherial blood of MIS-C patients during the disease and the period of health.

Full description

The study will consist of two parts. Initially, it will be of a cross-cutting comparative nature, when a group of healthy patients (control group) and a group of patients diagnosed with MIS-C/PIMS syndrome are compared with each other, based on nasal curettage swabs and peripheral blood, before the inclusion of systemic anti-inflammatory treatment (study group). In addition, an observation of the research group will be carried out, during which swabs and peripheral blood will be taken at two more control points.

Enrollment: 20 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• MIS-C diagnosis based of WHO diagnostic criteria.

Exclusion criteria

• immunosuppressive treatment received up to 3 months before
• intranasal drugs received up to 7 days before
• COVID-19 vaccination
• no consent

Trial design

20 participants in 2 patient groups

Control group

Description:

Healthy patients under 18 years of age.

MIS-C group

Description:

Patients with MIS-C diagnosed, based on WHO diagnostic criteria.