Study of Vitamin A and Carbomer in Comforting the Ocular Surface Irritations of Glaucoma Patients

Xiaodong Zhou

Status: Completed

Conditions: Primary Open-angle Glaucoma

Treatments: Drug: carbomer eye gel; Drug: Vitamin A

Study type: Interventional

Funder types: Other

Identifiers

NCT02077231

GlaucomaVitaminA

Details and patient eligibility

About

Most of the patients under long application of anti-glaucoma eyedrops endure severe ocular surface irritation, which interrupt their quality of life a lot. Lots of studies aimed to search for new drugs for therapy. The investigators hypothesized that the artificial tears containing vitamin A or carbomer may be a great substitute. Both of the two drugs were in common use and had already been tested in animals.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosed primary open-angle glaucoma or normal tension glaucoma patients with prostaglandin analogs treatment for more than one year.

Exclusion criteria

1. any systemic diseases which may cause ocular damage;
2. previous ocular trauma or surgery;
3. contact lens wear history in previous 6 months;
4. application of any artificial tears 3 months ago;
5. allergic to any of the drugs we used during examination.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

vitamin A palmitate eye gel

Experimental group

Description:

0.1% vitamin A palmitate; Sinqi, Shenyang, China

Treatment:

Drug: Vitamin A

carbomer eye gel

Experimental group

Description:

0.2% Carbomer 940; Bausch \& Lomb, Aschheim, Germany

Treatment:

Drug: carbomer eye gel