Study of Weekly Paclitaxel and Cisplatin in FIGO IB2 and IIA2 Cervical Cancer Followed by Radical Hysterectomy

Chang Gung Medical Foundation

Status and phase: Unknown; Phase 2

Conditions: Cervical Cancer

Treatments: Procedure: Radical hysterectomy and bilateral pelvic lymphadenectomy; Drug: paclitaxel; Drug: cisplatin

Study type: Interventional

Funder types: Other

Identifiers

NCT02432365

AGOG14-001/TGOG1008

IRB103-4781A3 (Other Identifier)

Details and patient eligibility

About

The purpose was to establish a quick (7-day) cycle schedule of paclitaxel (60 mg/m2) combining with cisplatin (40 mg/m2) NAC regimen could be tolerated without interfering the following surgical treatment and a favorable overall survival rate for stages IB2 and IIA2 cervical squamous cell carcinoma (SCC).

Full description

This is a multi-center, open-label, Simon's 2-stage, phase II study of paclitaxel and cisplatin as neoadjuvant therapy in patients with FIGO IB2 or IIA2, squamous cell cervical carcinoma of the uterine cervix.

Primary Objectives:

• Overall survival

Secondary Objectives:

• Safety
• Progression-free survival
• Response rate
• Postoperative RT/CRT rate
• To assess Quality-of-life

An estimate of 64 evaluable patients will be enrolled in this phase II investigation.

Enrollment: 64 estimated patients

Sex: Female

Ages: 35 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Women with previously untreated, histologically confirmed squamous cell carcinoma of the uterine cervix

2. HPV16-positive aged 35-70 years or HPV16-negative age <55 years

3. FIGO stage IB2 or bulky IIA, with tumor extending to the vagina within the upper one third of the vaginal wall. Bulky tumor is defined as

   1. a visible cervical tumor with the largest diameter >4 cm or (b) a cervix expanded to > 4 cm as a result of tumor infiltration by pelvic examination
   2. verified by magnetic resonance image (MRI) or 3-dimensional (D) computed tomography (CT)

4. no suspicious extrapelvic metastasis detected by MRI or 3-D CT

5. adequate marrow, liver and renal functions :hemoglobin level >= 10 g/dL, WBC count >= 3,000/mm3 or absolute neutrophil count >= 1,500/mm3, platelet count >= 100,000/mm3, serum transaminase (AST, ALT) levels <= 60 IU/mL, total serum bilirubin within normal range, serum creatinine level <= 1.5 mg/dL, and blood urea nitrogen level <=20 mg/dL

6. adequate cardiopulmonary function that tolerates the administration of study regimen and radical hysterectomy

7. Eastern Cooperative Oncology Group performance status of 0 to 1

8. had written informed consent to participate in the study

9. Appropriate organ and marrow function :

   leukocytes >=3,000/μL absolute neutrophil count >= 1,500/μL platelets >= 100,000/μL (not platelet transfusion dependent) hemoglobin >= 10 g/dL total bilirubin within normal range AST/ALT <= 2.5 X upper limit of normal range (ULN) BUN <= 20 mg/dL serum creatinine <=1.5 mg/dL or clearance > 60 mL/min

10. a negative urinary pregnancy test in a patient with child-bearing potential

Exclusion criteria

Patients will be excluded from the study if they meet any of the following criteria:

1. adenocarcinoma , adenosquamous carcinoma, or small cell carcinoma
2. concurrent or history of malignant tumor(s) other than treated nonmelanoma skin cancer
3. had received surgical procedure other than cervical biopsy or cytotoxic procedure including chemotherapy, radiotherapy or therapy with biologic response modifier(s) for the cervical tumor
4. enlarged pelvic lymph node with positive aspiration cytologic or histologic study
5. participate in investigational treatment or another clinical trial for cervical cancer
6. history of allergic reaction to platinum or paclitaxel
7. uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
8. pregnant or breast feeding women

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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64 participants in 1 patient group

Weekly paclitaxel and cisplatin

Experimental group

Description:

7-day cycle schedule of paclitaxel (60 mg/m2) combining with cisplatin (40 mg/m2) NAC regimen followed by radical hysterectomy and bilateral pelvic lymphadenectomy

Treatment:

Drug: cisplatin

Procedure: Radical hysterectomy and bilateral pelvic lymphadenectomy

Drug: paclitaxel