Study on Antibody Persistence and Immune Memory of Inactivated COVID-19 Vaccine

Centers for Disease Control and Prevention, China

Status: Completed

Conditions: COVID-19

Study type: Observational

Funder types: Other

Identifiers

NCT05072496

BJCDCWJ202101

Details and patient eligibility

About

The study describe 1 year durability of humoral and cellular immune responses in 150 individuals who received COVID-19 inactivated vaccine. all participants were recruited aged between 18 and 59 years old. Every participant was familiarized with the aim of the study and asked to sign an informed consent agreement, and be required blood sampling at the day 0 of first dose vaccine and 1 month, 3 months, 6 months and 12 months after fully vaccination separately. From every sample, 10 ml, 10 ml, and 5 ml were dispensed in three vacuum blood collection tubes. Peripheral blood lymphocytes cell (PBMC) were isolated with the two 10 ml samples contained heparin to detect immune memory cells and cytokines. RBD-IgG and neutralizing antibody be detected by 5ml sample from separating gel vacuum tubes. every individual conducted a detailed analysis comparing neutralizing antibody, TEM, TCM , and report on the cellular and humoral immunity 1 year after accept COVID-19 vaccine.

Enrollment: 150 patients

Sex: All

Ages: 18 to 59 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Working at the CDC
• Between the ages of 18 and 59
• Healthy
• Not vaccinated with COVID-19 vaccine
• Agreed to take a blood sample

Exclusion criteria

• who cannot take the COVID-19 vaccine due to some personal reasons
• history of SARS-CoV, SARS-CoV-2, or Middle East respiratory syndrome infection
• high-risk epidemiology history within 14 days before enrolment (eg, travel or residence history in communities with case reports, or contact history with someone infected with SARS-CoV-2)
• axillary temperature of more than 37·0℃
• history of allergy to any vaccine component.