Study on Baroreceptor Function in Relation to Orthostatic Blood Pressure Regulation After Hip Surgery

Rigshospitalet

Status: Unknown

Conditions: Hypotension, Orthostatic; Total Hip Replacement

Study type: Observational

Funder types: Other

Identifiers

NCT01866787

RH-4074-OJ3

Details and patient eligibility

About

The purpose of this observational study is to evaluate the baroreceptor function in relation to surgical inflammation and orthostatic intolerance after elective hip arthroplasty.

The main hypothesis is that baroreceptor function is attenuated after surgery and related to surgical inflammation.

Full description

Orthostatic intolerance and hypotension is prevalent during early mobilization after major surgery.

This observational study aims to evaluate the baroreceptor function during using a standardized evaluation protocol before, 6- and 24 hours after elective primary unilateral hip-arthroplasty.

The study hypothesis is that baroreceptor function as expressed by the valsalva ratio is attenuated after surgery and related to surgical inflammation.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Scheduled for unilateral hip arthroplasty
• 18 years or older
• Able to give informed consent

Exclusion criteria

• American Society of Anesthesiologists (ASA) class 3 or higher
• Chronic arrythmia (Atrial fibrillation or other arrythmia)
• Incompensated ischaemic heart disease
• Mobilization restriction due to surgical reasons
• Medical complications during admission requiring transferral to other department

Trial design

30 participants in 1 patient group

Study cohort