Study on Brain Structure and Function of Pain-related Emotion Disorder

Zhoujie

Status: Unknown

Conditions: Depressive Symptoms; Osteoarthritis, Knee; Anxiety State

Treatments: Diagnostic Test: Functional magnetic resonance examination

Study type: Observational

Funder types: Other

Identifiers

NCT03912610

2019-01

Details and patient eligibility

About

By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.

Full description

In this study, 5 patients with knee osteoarthritis and 5 healthy volunteers were selected. The degree of pain is evaluated via visual analogue pain scale (VAS). The emotional state is evaluated by Hamilton anxiety scale (HAMA) or Hamilton depression scale (HAMD). The patients and healthy volunteers who meet the include criteria are include in the research. Then the spontaneous brain electrical activity is collected by multimodal brain magnetic resonance imaging technology. The spontaneous brain electrical activity is analyzed to find the differences between knee osteoarthritis patients and healthy volunteers. Further analysis of resting brain functional connectivity and information exchange changes in multifunctional areas, in order to elaborate the central mechanism of pain and emotion modulation.

Enrollment: 5 estimated patients

Sex: All

Ages: 35 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

The experimental group was selected as:

• Meet the above diagnostic criteria.
• VAS scale score > 4 points.
• HAMA score > 14 or HAMD score > 17 points.
• Agree to participate in the survey and submit an informed consent form.

The control group was selected as:

• Healthy volunteers who exclude knee osteoarthritis.
• VAS scale score ≤ 4 points.
• HAMA score ≤14 or HAMD score ≤ 17 points.
• Agree to participate in the survey and submit an informed consent form

Exclusion criteria

• Rheumatoid arthritis, psoriatic arthritis, gouty arthritis, bone erosion, bone tuberculosis, bone tumor patients.
• Clear diagnosis of traumatic meniscus, cruciate ligament, collateral ligament injury history and patients with history of knee trauma in the past six months.
• Have a heavier heart, brain and other medical conditions and poor overall health.
• In pregnancy, pregnancy or lactation.
• Taking antidepressant and anxiety drugs.
• Participated in other clinical studies within 2 months prior to the start of the study.
• The patient or his licensor is unwilling to sign a written informed consent or is unwilling to follow the research protocol.

Trial design

5 participants in 2 patient groups

Health control group

Description:

5 health volunteer are included in the group. Each volunteer will take the functional magnetic resonance examination one to collect the data.

Treatment:

Diagnostic Test: Functional magnetic resonance examination

Knee osteoarthritis group

Description:

5 patients of knee osteoarthritis accompanied with depression or anxiety are included in the group. Each volunteer will take the functional magnetic resonance examination one to collect the data.

Treatment:

Diagnostic Test: Functional magnetic resonance examination