Study on Clinical Outcome of Vascular Inflow Occlusion in Open Liver Resection

The Chinese University of Hong Kong

Status: Completed

Conditions: Hepatectomy

Treatments: Procedure: Intermittent Pringle maneuver

Study type: Interventional

Funder types: Other

Identifiers

NCT00730743

CT08017

CRE-2008.037-T

Details and patient eligibility

About

This study aims to evaluate whether applying inflow vascular occlusion in modern liver resection is associated with better clinical outcome.

Eligible patients are randomly assigned to the two surgical techniques: with or without the application of inflow vascular occlusion.

Patients outcome including liver function recovery, operative time and blood loss are compared.

Enrollment: 126 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Child-Pugh Class A or B

Exclusion criteria

• Informed consent not available
• Presence of portal vein thrombosis, portal vein tumor thrombus, or previous portal vein embolisation
• Presence of hepatic artery thrombosis, previous transarterial therapy like TACE, or transarterial internal radiation
• When portal vein resection is anticipated
• Emergency hepatectomy
• Ruptured hepatocellular carcinoma
• Rehepatectomy (repeated liver resection)
• Adhesion or anatomical variation that preclude safe and successful application of Pringle maneuver
• When concomitant bowel or bile duct resection is anticipated

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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126 participants in 2 patient groups

1

Experimental group

Description:

Intermittent clamp group

Treatment:

Procedure: Intermittent Pringle maneuver

2

No Intervention group

Description:

No clamp group