Study on Clinical Value of Vitamin D in Recurrent Spontaneous Abortion

Jianmei Xia

Status: Completed

Conditions: Vitamin D Deficiency; Recurrent Spontaneous Abortion

Treatments: Dietary Supplement: Binom Vitamin D drops

Study type: Observational

Funder types: Other

Identifiers

NCT06002035

2023002

Details and patient eligibility

About

The observational study is to compare vitamin D deficiency and related indicators among different spontaneous abortions in describe female reproductive health.The main question aim to answer is: the possible pathogenesis of recurrent spontaneous abortion caused by vitamin D.

Participants, who visit the RSA specialty clinic, will provide medical history information, regularly exam based on the condition, following up on pregnancy status.Participants will be asked to supply vitamin D preparation and do moderate exercise outdoors, comparing the effect after treatment.

Full description

Examinations include uterine artery resistance parameter S/D, some embryonic chromosomes tested voluntarily, plasma VD content and the level of anticardiolipin antibody.

Enrollment: 1,421 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of patients without spontaneous abortion;
• Clinical diagnosis of patients with a spontaneous abortion;
• Clinical diagnosis of patients with recurrent pontaneous abortions;

Exclusion criteria

• Patients with chromosomal abnormalities in RSA couples, such as balanced translocation;
• Patients who take VD preparations or related VD supplements within 3 months before treatment;
• Patients with a combination of certain malignant tumors and severe mental illness.

Trial design

1,421 participants in 3 patient groups

patients without spontaneous abortion(SA0)

Description:

The patients with VD deficiency or insufficiency take 30 drops (relative to 1ml) once a day, directly into the mouth or with complementary foods added.

Treatment:

Dietary Supplement: Binom Vitamin D drops

patients with a spontaneous abortion(SA1)

Description:

The patients with VD deficiency or insufficiency take 30 drops (relative to 1ml) once a day, directly into the mouth or with complementary foods added.

Treatment:

Dietary Supplement: Binom Vitamin D drops

patients with RSA (SA2 and above)

Description:

The patients with VD deficiency or insufficiency take 30 drops (relative to 1ml) once a day, directly into the mouth or with complementary foods added.

Treatment:

Dietary Supplement: Binom Vitamin D drops