Study on Cognitive Impairment of Insomnia Based on MRI

Tang-Du Hospital

Status: Enrolling

Conditions: MRI; Cognitive Disorder; Insomnia

Treatments: Diagnostic Test: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT05659511

202211-16

Details and patient eligibility

About

Insomnia is a common sleep disorder. In recent years, the incidence of insomnia is increasing worldwide. Studies point out that insomnia plays an important role in the pathogenesis of cognitive impairment. Although sleep and cognitive scales are the main methods to detect sleep quality and cognitive changes, there are problems such as strong subjectivity and poor repetition. There is an urgent need to use non-invasive and objective detection methods to assess the potential mechanisms of cognitive impairment caused by sleep disorders. Previous studies have shown that different brain states may show different neurovascular coupling (NVC) characteristics. However, after prolonged sleep deprivation, the evoked hemodynamics response was attenuated despite an increased electroencephalogram (EEG) signal response, suggesting that sustained neural activity may reduce vascular compliance. It is suggested that sleep disorder may lead to NVC disorder. However, whether sleep disorders regulate the mechanism of cognitive impairment in the brain through NVC disorders has not been demonstrated in vivo. Currently, functional magnetic resonance imaging (fMRI) can be used to study brain function and blood flow changes non-invasively. In our previous research, we combined cerebral blood flow (CBF) with mean amplitude of low-frequency fluctuation (mALFF), mean regional homogeneity (mReHo) and degree-centrality (DC), the early warning effect of fMRI features based on neurovascular uncoupling on early cognitive impairment was confirmed, providing a basis for further selection of functional imaging indicators. In conclusion, the present study proposes the scientific hypothesis that neurovascular decoupling-based MRI features are more appropriate for exploring the neural mechanisms underlying sleep disorders-induced brain cognitive impairment. The aim of this study is to establish an early warning and monitoring system for early non-invasive diagnosis and intervention of sleep-related cognitive impairment.

Enrollment: 684 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sleep score meets the group standard
• Education time more than 8 years
• Without dementia
• Inform Consent Form

Exclusion criteria

• Pregnant woman
• Suffer from serious brain disease
• Magnetic resonance contraindications
• Image quality is too poor to deal with
• Lack of compliance

Trial design

684 participants in 3 patient groups

healthy control group

Description:

Healthy people neither in insomnia group nor in MCI group.

Treatment:

Diagnostic Test: MRI

insomnia

Description:

Pittsburgh sleep quality index (PSQI)\>5, Epworth Sleepiness Scale (ESS)\>9 ，Insomnia Severity Index (ISI)\>8.

Treatment:

Diagnostic Test: MRI

insomnia-MCI

Description:

Pittsburgh sleep quality index(PSQI)\>5 ,Epworth Sleepiness Scale(ESS)\>9 ，Insomnia Severity Indeex(ISI)\>8; 20\< MoCA\<26.

Treatment:

Diagnostic Test: MRI