Study on Correlated Factors of Barrier and Immune Function in Stress Related Mucosal Disease (SRMD)

Xiuli Zuo

Status: Completed

Conditions: Stress Related Mucosal Disease

Treatments: Other: Endoscopy biopsy and blood

Study type: Interventional

Funder types: Other

Identifiers

NCT03200158

2015SDU-QILU-G006

Details and patient eligibility

About

To study the changes of barrier and immune function in Stress Related Mucosal Disease (SRMD).

Full description

38 patients admitted to ICU and 15 healthy volunteers were successively enrolled in this study.The healthy volunteers were treated with endoscopy and biopsy .The 38 patients were treated with bedside gastroscopy and diagnosed with SRMD due to illness. The acute physiology and chronic health evaluation（APACHE）II score were evaluated, malondialdehyde (MDA) as an index of oxygen radical-lipid peroxidation was assessed in the serum. Transforming growth factor(TGF)β1,claudin3, interleukin (IL) 1 and interleukin（IL）10 levels in the gastric mucosa and plasma level of superoxide dismutase(SOD)，Ischemic modified albumin(IMA)and C-reactive protein（CRP）were evaluated.

Enrollment: 53 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Occurrence time: ≤72h.
• With complete clinical data.
• Patients admitted to ICU were treated with bedside endoscopy and diagnosed with SRMD.

Exclusion criteria

• Primary digestive tract diseases included stomach cancer, gastric ulcer, cirrhosis with esophagus fundus ventricularis varices and esophageal cancer.
• Patients were complicated with gastric perforation.
• Nonsteroidal anti-inflammatory drugs and antiplatelet agents had been used recently, or with the history of major surgery.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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53 participants in 1 patient group

Endoscopy biopsy and blood

Other group

Description:

The healthy volunteers were treated with endoscopy biopsy and blood.The patients were treated with bedside endoscopy biopsy and diagnosed with SRMD due to illness，then collect their blood samples.

Treatment:

Other: Endoscopy biopsy and blood