Study on Correlation Between Vascular ET-1 and Adiponectin in Pediatric Obesity

Monica Montagnani

Status: Unknown

Conditions: OBESITY; Endothelial Dysfunction; Insulin Resistance

Study type: Observational

Identifiers

NCT01750333

OBETAD-01

Details and patient eligibility

About

The aim of this study is to explore whether and how high circulating levels of endothelin-1 (ET-1) in obese and overweight children may contribute to impair adiponectin (Ad) production, release and vascular activity

Enrollment: 60 estimated patients

Sex: All

Ages: 5 to 13 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children will be enrolled into lean, overweight or obese groups based on Body mass index (BMI) calculated according to standard methods. International standards for sex-and age-specific BMI centiles for subjects aged 2-18 years will be used. The 95th centile of BMI reference is the cut off point for childhood obesity. Overweight and obese children are defined as those with a BMI higher than the centile curves.

Exclusion criteria

• presence of renal, liver and/or cardiovascular diseases;
• hypertension;
• metabolic and/or endocrine disorders;
• genetic syndromes;
• histories of chronic allergies, acute infectious or inflammatory diseases during the last 3 months preceding the study

Trial design

60 participants in 3 patient groups

Lean children

Overweight Children (OW)

Obese children (Ob)