Study on Efficacy and Safety of Human Albumin in Burn Shock Recovery

Zhejiang University

Status: Completed

Conditions: Burns Shock

Treatments: Drug: Albumin

Study type: Observational

Funder types: Other

Identifiers

NCT04928859

2020-489

Details and patient eligibility

About

To explore the effects and safety of human albumin in burn shock recovery, and then provide a theoretical basis for its rational use.

Full description

A retrospective case-control study was conducted. Patients who admitted to the burn ward and needed fluid resuscitation during the period of January 2011 to December 2018 in our unit were identified. Patients were divided into two groups according to the severity of burns, the patients with a 20%<TBSA≤50% constituted the moderate and severe burn group, the patients with a TBSA>50% constituted the severest burn group, and then the patients who used albumin for resuscitation constituted the albumin group, the patients who did not use albumin constituted the control group. The primary outcome was mortality, and the secondary outcomes included hospital stay, ventilator supporting, fluid use, and complications.

Enrollment: 364 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18
• TBSA≥ 20% （TBSA，the total burn area.）
• Admitted to hospital within 24 hours after injury.

Exclusion criteria

• STB ≥ 33 μ mol/L
• Cr ≥ 171 μ
• Urine output l< 500 ml / 24 h
• Pregnant and lactating women
• Severe combined injury
• Glucocorticoids users
• Immunosuppressants users
• Patients survived less than 48 hours

Trial design

364 participants in 2 patient groups

the albumin group

Description:

The albumin group, the patients who used albumin for resuscitation during their hospitalization in the burn ward constituted the albumin group.

Treatment:

Drug: Albumin

the control group

Description:

The control group, the patients who did not use albumin during their hospitalization in the burn ward constituted the control group.