Study on Genetically Affected Sporadic Thoracic Aortic Aneurysm and Dissection (GenSTAND)

Wuhan Asia Heart Hospital

Status: Completed

Conditions: Dissection of Aorta, Thoracic; Aneurysm of Aorta, Thoracic

Study type: Observational

Funder types: Other

Identifiers

NCT02852603

2016LMC-2

Details and patient eligibility

About

Mortality of thoracic aortic aneurysm and dissection (TAAD) remains high because of the huge blood lost from the aorta. Questions about the potentially genetic effects on sporadic TAAD are raised by researchers to explore the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Full description

Thoracic aortic dissection (TAD) is a critical clinical condition partly due to the rupture of aortic aneurysm. Mostly, surgical treatment can reduce the symptoms and extend life span of patients with thoracic aortic aneurysm and dissection (TAAD). However, mortality of TAAD remains high because of the huge blood lost from the aorta. Sporadic TAAD was considered to be a server consequence of hypertension, though most patients with hypertension won't have TAAD as their final outcomes. Previous studies have revealed the associations between genetic abnormalities and familial TAAD, and genetic tests have applied to assist the diagnosis of certain TAAD. Therefore, the potentially genetic effects on sporadic TAAD are explored by researchers to understand the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Enrollment: 450 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with thoracic aortic aneurysm and dissection not due to trauma

Exclusion criteria

• Inability of the patient, parent or guardian to give consent
• Unwillingness to provide a blood specimen or participate in the study

Trial design

450 participants in 1 patient group

thoracic aortic aneurysm and dissection

Description:

Patients with thoracic aortic aneurysm and/or dissection are recruited in the study.