ClinicalTrials.Veeva

Menu

Study on Left Atrial Function of Atrial Fibrillation After Radiofrequency Ablation With Statin Therapy

X

xieruiqin

Status

Completed

Conditions

Atrial Fibrillation

Treatments

Drug: atorvastatin group
Drug: non-atorvastatin group

Study type

Interventional

Funder types

Other

Identifiers

NCT02776956
xierqdoctormd

Details and patient eligibility

About

A total of 120 patients with persistent atrial fibrillation (including continuous and long-standing persistent atrial fibrillation) and 60 patients with paroxysmal atrial fibrillation will receive radiofrequency ablation. Patients in each group will be randomly allocated into the statin treatment group and non-statin treatment group (allocation ratio, 1:1). Left atrial appendage flow velocity of all patients are measured by Transesophageal Echocardiography(TEE) 24 hours before the operation. Real-time ultrasound examinations of left atrial function are carried out for all patients before the operation and after the operation. Blood samples are extracted in all patients before the operation and after the operation. This study will clarify whether the application of statin drugs can improve postoperative left atrial function. This study will identify the time course and influence factors of left atrial recovery of atrial fibrillation after the operation to guide the time and the degree of anticoagulation and effectively prevent thromboembolic events. At the same time, biochemical indicators are detected to analyze which indicators are related to the postoperative recurrence of atrial fibrillation, the incidence of postoperative thrombosis and the recovery of postoperative left atrial function. Furthermore, this study will investigate whether the application of statin drugs can improve postoperative left atrial function by affecting these indicators.

Enrollment

180 patients

Sex

All

Ages

Under 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All persistent or permanent AF patients with refractory or intolerant to at least one Class 1 or Class 3 antiarrhythmic medication.
  • paroxysmal atrial fibrillation with refractory or intolerant to at least one Class 1 or Class 3 antiarrhythmic medication.
  • age is <80 years

Exclusion criteria

  • left ventricular dysfunction
  • LA >50 mm
  • atrial thrombosis
  • valvular heart disease
  • hyperthyroidism
  • patients who underwent prosthetic heart valve replacement
  • patients with previous history of atrial fibrillation ablation
  • Hyperlipidemia
  • pregnant women
  • patients with existing liver and kidney disease
  • malignant tumors
  • hematological system diseases

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

180 participants in 2 patient groups

atorvastatin group
Experimental group
Description:
atrial fibrillation in atorvastatin group will orally receive atorvastatin before and after operation.
Treatment:
Drug: atorvastatin group
non-atorvastatin group
Other group
Description:
atrial fibrillation in non-atorvastatin group will not receive atorvastatin before and after operation..
Treatment:
Drug: non-atorvastatin group

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems