Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy (FaisPLASTICITE)

Grenoble Alpes University Hospital Center (CHU)

Status

Completed

Conditions

Epilepsy

Treatments

Other: MRI exam

Study type

Interventional

Funder types

Other

Identifiers

NCT03543267

38RC17.018

Details and patient eligibility

About

This study consist of define anatomo-functional reorganization (plasticity) profiles for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.

For that, patients will have 2 MRI examinations, one before surgery and the second, between 3 and 8 months after surgery.

Enrollment

37 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with diagnosis of pharmaco-resistant focal epilepsy
Patient candidate for surgery to resect the epileptogenic zone
Patients affiliated to a social security scheme or beneficiaries of such a scheme
Patients with French as their mother tongue
Patients who have given signed informed consent before performing any procedure related to the study.

Exclusion criteria

Contraindication to performing an MRI:
Intellectual disability objectified by a Mini Mental Score (MMS) score <24 in the year preceding inclusion,
Existence of a severe condition in general: cardiac, respiratory, hematological, renal, hepatic, cancerous,
Participation in other research protocols underway with exclusion period or in the previous week,
Persons referred to in Articles L1121-5 to L1121-8 of the Public Health Code.