Study on Prognosis of Acute-on-chronic Liver Failure Complicated by Bacterial or Fungal Infection

Qin Ning

Status: Enrolling

Conditions: Acute-On-Chronic Liver Failure

Study type: Observational

Funder types: Other

Identifiers

NCT06437067

ACLF-I

Details and patient eligibility

About

The subjects of this study were inpatients with ACLF who were admitted to Tongji Hospital in Wuhan from March 2023 to June 2025. After patients were enrolled, The patient's general information (gender, age, past medical history, etc.), complications (ascites, hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding, etc.), laboratory tests (CRP, PCT, INR, WBC, fungal/bacterial diagnostic tests, etc.), symptoms and signs at the time of infection, and at admission (D1), D4, D7, D14, D21, etc.) were recorded Save the blood separately. The patients were divided into fungal infection group, bacterial infection group and non-infection group according to the infection status after admission.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. TBIL ≥ 12 mg/mL and INR ≥ 1.5
2. Chronic hepatitis B

Exclusion criteria

(1) <18 or >80 years old; (2) primary hepatic or extrahepatic carcinoma; (3) with severe diseases of other organs or systems; (4) pregnancy; (5) imcomplete information

Trial design

400 participants in 3 patient groups

non-infection group

Description:

patients without bacterial or fungal infection

bacterial infection group

Description:

patients with bacterial infection

fungal infection group

Description:

patients with fungal infection