Study on Single-nucleotide-polymorphism in Idiopathic Membranous Nephropathy

Shanghai University of Traditional Chinese Medicine

Status: Unknown

Conditions: Idiopathic Membranous Nephropathy

Treatments: Drug: The Comprehensive Treatment Regimen of Traditional Chinese Medicine; Drug: The immunosuppressive agents

Study type: Observational

Funder types: Other

Identifiers

NCT01799460

11YZ65 (Other Grant/Funding Number)

ShanghaiMEC-2011

Details and patient eligibility

About

The purpose of this study is to analysis the different genotype in the idiopathic membranous nephropathy patients which with different therapeutic outcomes after treated by the Comprehensive Treatment Regimen or immunosuppressive agents, and so as to looking for ideal markers to assess appropriate treatment approach and the long-term efficacy.

Full description

The primary objective of this study is to looking for the gene level predictors in the patients who suffered from idiopathic membranous nephropathy. And according to the predictors, the clinicians could make a decision which method should be taken on IMN patients, Traditional Chinese Medicine or western medicine, and could get better results.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of idiopathic membranous nephropathy
• Chronic Kidney Disease (CKD)≤3 stage（Glomerular Filtration Rate (GFR)≥30ml/min）and 24 hour urinary protein≥3g
• Voluntarily participated in the study and signed an informed consent

Exclusion criteria

• Combined life-threatening complications such as serious infection
• Abnormal glucose metabolism
• Patients with malignant tumors or malignancy , HIV infection and a history of mental illness , acute central nervous system disease , serious gastrointestinal diseases,etc
• Pregnancy or breast-feeding women
• Undergoing other clinical trials

Trial design

80 participants in 4 patient groups

CR/CTR group

Description:

The complete remission group treated by the Comprehensive Treatment Regimen

Treatment:

Drug: The Comprehensive Treatment Regimen of Traditional Chinese Medicine

NR/CTR group

Description:

The non-remission group treated by the Comprehensive Treatment Regimen

Treatment:

Drug: The Comprehensive Treatment Regimen of Traditional Chinese Medicine

CR/IA group

Description:

The complete remission group treated by Immunosuppressive Agents

Treatment:

Drug: The immunosuppressive agents

NR/IA group

Description:

The non-remission group treated by Immunosuppressive Agents.

Treatment:

Drug: The immunosuppressive agents