Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics

Dow University of Health Sciences

Status: Unknown

Conditions: Diabetes Mellitus

Study type: Observational

Funder types: Other

Identifiers

NCT00698698

Tear proteins

Details and patient eligibility

About

Diabetes mellitus is becoming a global epidemic. There is a need to devise a non invasive method for detection of diabetes and its related complication. Tear proteins are easy to collect causing no harm to a patient and different studies indicate that tear proteins of diabetic patients are significantly different from non diabetic population. This difference in the composition of tear proteins become more pronounced with advancement of diabetic retinopathy.

Full description

Diabetes mellitus causes a significant alteration in tear proteins. If we analyze tear proteins by means of electrophoresis, HPLC, and mass spectroscopy.

We can find different type of tear proteins in different grades of diabetic retinopathy these biomarkers can help in mass screening , diagnosis and management of diabetic population.

Enrollment: 350 estimated patients

Sex: All

Ages: 30 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diabetic patients with type 2 diabetes
• age above 30
• willing to participate

Exclusion criteria

• ocular surface disorders.
• collagen vascular diseases
• Limbal hyperemia
• previous ocular surgery
• creatinine level above 1.0
• liver diseases

Trial design

350 participants in 5 patient groups

Non diabetic

Description:

Normal age and sex matched population

Grade 1

Description:

Diabetic population with no retinopathy or Mild non proliferative diabetic retinopathy

Grade 2

Description:

Moderate non proliferative diabetic retinopathy

Grade 3

Description:

Severe non proliferative diabetic retinopathy

Grade 4

Description:

Proliferative diabetic retinopathy and advanced diabetic eye disease