Study on the Correlation Between Neurotrophic Factors and the Condition of Stroke Patients

Chongqing Medical University

Status: Enrolling

Conditions: Stroke

Treatments: Procedure: acupuncture; Behavioral: computerized cognitive training system; Behavioral: aerobic exercise; Other: Conventional treatment; Behavioral: tranditional cognitive training

Study type: Interventional

Funder types: Other

Identifiers

NCT05479903

2021kelunshen110

Details and patient eligibility

About

Stroke is currently the most common disabling disease, which often leads to impairment of sensory, motor, speech and psychological functions, resulting in a reduced quality of life for patients. Therefore, post-stroke functional rehabilitation, especially the rehabilitation of physical function and psychological condition, is particularly important for patients to rejoin society. Acupuncture can promote the functional recovery of patients and facilitate the rehabilitation of limb function, thus improving the quality of survival of post-stroke patients.

Neurotrophic factors are diverse, most of which are mainly derived from neuronal cells in the central nervous system and are involved in a variety of neurological functions such as cell growth, differentiation and plasticity, thus promoting recovery of multiple functions after stroke. Many studies have found that different interventions affect the prognosis of stroke patients differently, e.g., long-term acupuncture increases serum levels of brain-derived neurotrophic factor in stroke patients and also has better outcomes than controls in post-stroke neurological recovery and the development of post-stroke psychiatric disorders.

This study investigated the effects of different therapeutic measures on patients' functional recovery and neurotrophic factors by setting up a controlled and blinded trial design, which could not only provide clinical evidence for the effectiveness of relevant therapeutic measures, but also verify the clinical value of certain neurotrophic factors (e.g., predicting outcome, assessing condition, and preventing adverse events).

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Symptom recognition to admission ≤ 72 hours
• Clear imaging evidence
• Diagnosis of spontaneous cerebral hemorrhage by an immobilized physician according to relevant guidelines; pre-onset mRS score ≤ 1

Exclusion criteria

• This onset was caused by traumatic and violent factors
• History of previous intracranial surgery
• Previous cerebrovascular accident
• Previous speech disorders and limb movement disorders
• Participation in other trials in the last three months.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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300 participants in 7 patient groups, including a placebo group

acupuncture stroke group

Experimental group

Treatment:

Procedure: acupuncture

Other: Conventional treatment

sham acupuncture stroke group

Sham Comparator group

Treatment:

Other: Conventional treatment

no acupuncture stroke group

Placebo Comparator group

Treatment:

Other: Conventional treatment

acupuncture healthy group

Placebo Comparator group

Treatment:

Procedure: acupuncture

computerized cognitive training group

Experimental group

Treatment:

Behavioral: computerized cognitive training system

Other: Conventional treatment

tranditional cognitive training group

Placebo Comparator group

Treatment:

Behavioral: aerobic exercise

Other: Conventional treatment

aerobics group

Experimental group

Treatment:

Behavioral: tranditional cognitive training

Other: Conventional treatment