Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.

Xijing Hospital of Digestive Diseases

Status: Completed

Conditions: Gastric Cancer; Intestinal Metaplasia; Helicobacter Pylori Infection; Precancerous Lesions; Bile Reflux Gastritis

Study type: Observational

Funder types: Other

Identifiers

NCT03976739

KY20191026-F-1

Details and patient eligibility

About

To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.

Full description

This study was a multicenter cross-sectional study. Patients were consecutively enrolled and divided into gastric cancer group, gastric precancerous lesions group, and chronic gastritis group, according to histopathological results. The bile reflux detection rate and Helicobacter pylori infection status were recorded for each group.

Enrollment: 1,162 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age 18 to 75 years old, gender is not limited;
2. patients with upper abdominal pain, abdominal distension, belching, anorexia, early satiety, hiccup, acid reflux, upper abdomen burning sensation and other upper gastrointestinal symptoms;
3. Voluntary acceptance of Hp testing;
4. Voluntary acceptance of the endoscopy and pathological biopsy.

Exclusion criteria

1. had undergone upper gastrointestinal surgery;
2. Previous diagnosis of esophageal cancer;
3. Previous diagnosis of gastric cancer;
4. Previous diagnosis of MALT lymphoma;
5. pregnant and lactating women;
6. Those with mental disorders;
7. Refusal to sign the informed consent form.

Trial design

1,162 participants in 3 patient groups

chronic gastritis

Description:

patients with chronic non-atrophic gastritis and chronic atrophic gastritis according to histopathological results

precancerous lesion

Description:

patients with gastric intestinal metaplasia and intraepithelial neoplasia according to histopathological results

gastric cancer

Description:

patients with gastric cancer according to histopathological results