Study on the Effect of Transcranial Magnetic Stimulation on the Perception of Emotional Images (SAME-M)

Prof. Dominique de Quervain, MD

Status

Enrolling

Conditions

Emotional Memory

Treatments

Device: Control continuous 30 Hz thetaburst transcranial magnetic stimulation

Device: Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT07191275

2025-01622

Details and patient eligibility

About

The goal of the current clinical trial is to investigate whether transcranial magnetic stimulation (TMS) over specific brain areas can influence the perception of emotional images and emotional memory. TMS is a non-invasive superficial brain stimulation generated by a magnetic field. The results of the study aim to provide valuable insights for the use of TMS in the investigation of mental processes.

Enrollment

33 estimated patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Generally healthy
Normotensive (BP 90/60mmHg - 140/90mmHg)
BMI: 18 - 30 kg/m2
Fluent in speaking German

Exclusion criteria

Metal in the head area (e.g., splinters, fragments, clips, etc.)
Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS)
Cardiac pacemaker or intracardiac lines
Medication infusion device
Non removable metal piercings in the head area, pivot teeth (retainers are no exclusion criterion)
Tattoos (head area) less than 3 months old or older than 20 years
Condition after neurosurgery
Hearing problems or tinnitus
Not able to sit still due to tremor, tics, itching
History of repeated syncope
Head trauma diagnosed as concussion or associated with loss of consciousness
diagnosis of epilepsy, or a convulsion or a seizure in the past of the participant or his/her close family (parents and siblings)
TMS in the past showing problems
Spinal or ventricular derivations
Positive pregnancy test
Alcohol intake 12 hours before TMS visits
Regular intake of any medication (excluding oral contraceptives)
CNS-active medication or illegal drugs 48h before TMS visits
Individual's rMT above the limits of rTMS device
Suicidal tendency as measured by Montgomery-Åsberg Depression Rating Scale (MADRS), item 10 > 0