Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke

Air Force Military Medical University of People's Liberation Army

Status: Not yet enrolling

Conditions: Liver Injury; Heat Stroke; Early Waking; MODS; Kidney Injury; Proteinosis

Treatments: Diagnostic Test: Peripheral blood test

Study type: Observational

Funder types: Other

Identifiers

NCT05155358

KY20212173

Details and patient eligibility

About

Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.

Full description

The project intends to collect the peripheral blood of the normal population, the 24 hours after the onset of heat stroke and the patients in the recovery period, to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to search for indicators related to disease deterioration and prognosis, construct and verify the early warning and prognosis evaluation system of the disease.

On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of heat stroke, and then clarify the treatment target of heat stroke.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. The patient voluntarily signs an informed consent form;
2. Adult patients who meet the criteria for heat stroke;
3. Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ damage.

Exclusion criteria

1. Age <18 years old or >90 years old;
2. Patients with advanced tumors, Pregnancy or lactation;
3. Patients who missed out during treatment and whose data are incomplete.

Trial design

150 participants in 3 patient groups

Control group

Description:

Healthy volunteers

Treatment:

Diagnostic Test: Peripheral blood test

Patients within the acute phase of disease

Description:

Patients within 24 hours after onset

Treatment:

Diagnostic Test: Peripheral blood test

Recovery stage of disease

Description:

Organ dysfunction was corrected, The patient had no obvious discomfort.

Treatment:

Diagnostic Test: Peripheral blood test