Study on the Mechanism of ZhenQiFuZheng in the Treatment of Allergic Rhinitis Based on Intestinal Flora and Metabolites

Nanjing Medical University

Status

Enrolling

Conditions

Rhinitis, Allergic

Treatments

Drug: ZhenQi FuZheng granules (ShiDaiYangGuang)

Study type

Interventional

Funder types

Other

Identifiers

NCT06427577

2024-SR-304 ZhenQiFuZheng

Details and patient eligibility

About

ZhenQi FuZheng granules has been used to improve the immune function of human body, protect the bone marrow and adrenal cortex function and promote the recovery of positive function in traditional Chinese medicine care, especially with the immune imbalance diseases like post-surgery, chemotherapy and rhinitis. This project intends to establish AR（allergic rhinitis）specimen library, cell and animal model experiment, combining clinical cohort research with applied basic research, further assess the therapeutic mechanism of ZhenQiFuZheng granules in AR. We assume that ZhenQi FuZheng granules could cause the metabolic omics changes of nasal inflammatory factors and nasal secretions in AR patients, thus improving the type 2 inflammation level of allergic rhinitis.

Enrollment

40 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Adult patients (18-65 years).
Patients who visited the Department of Otolaryngology of the First Affiliated Hospital of Nanjing Medical University and are diagnosed as allergic rhinitis .

Exclusion criteria

Patients who refused to accept specimen and questionnaire collection.
Patients who had nasal diseases other than allergic rhinitis, such as nasal papilloma and nasal malignant tumor.