Study on the Myocardial Protective Effect of Upper Limb Ischemic Preconditioning in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
Status
Conditions
Treatments
Details and patient eligibility
About
The purpose of the study was to verify the myocardial protective effect of RIPC in patients undergoing OPCABG.
Full description
66 patients scheduled for OPCABG are randomly assigned to a RIPC group(n=33) or a control group(n=33). In the RIPC group, 4 cycles of 5-min ischemia(using a blood pressure cuff inflated to 40mmHg over the patient's basic blood pressure) and 5-min repercussion are done on an upper limb before skin incision. Patients in the control group wear the same cuff on an upper limb but no pressure is applied. Anesthetic and surgical techniques are standardized during the trial. Serum inflammatory cytokines and cardiac injury markers will be measured before and after surgery. Internal mammary artery and saphenous vein tissues will be collected during the surgery to assess hypoxia-inducible factor (Hif)-1a and other signalling proteins.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- serious changes in several coronary arteries that need to receive OPCABG
- NHYA II-III
- ASA II-III
Exclusion criteria
- LVEF< 35%
- acute myocardial infarction
- multiple organ dysfunction
Trial design
Primary purpose
Allocation
Interventional model
Masking
66 participants in 2 patient groups
Trial contacts and locations
Loading...
Central trial contact
Ke-fang Guo, Phd
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal