Study on the Pathogenesis of Retinal Vascular Diseases Based on Body Fluid Metabolomics

Zhongnan Hospital

Status: Invitation-only

Conditions: Metabolomics; Retinopathy; Etiology

Treatments: Other: etiology

Study type: Observational

Funder types: Other

Identifiers

NCT06408571

20240202

Details and patient eligibility

About

Through the analysis of metabolites in body fluids (intraocular fluid, plasma) of patients with retinal vascular diseases (retinal vein occlusion, diabetic retinopathy), the possible pathogenesis of retinal vein occlusion was explored.

Full description

1. Clinical data of patients with RVO and DR Were retrospectively studied to analyze their pathogenesis. 2. Metabolomic studies were conducted on body fluids (intraocular fluid and peripheral blood) of patients with RVO and DR And control group to find out the differences and find new targets for the prevention and treatment of RVO and DR.

Enrollment: 3,900 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥18 years old
• Confirmed diagnosis of retinal vein obstruction and diabetic retinopathy through ophthalmic specialist examination

Exclusion criteria

• Severe systemic diseases
• Pregnant and lactating patients

Trial design

3,900 participants in 2 patient groups

Experimental group

Description:

Patients with retinal vein obstruction and diabetic retinopathy

Treatment:

Other: etiology

Control group

Description:

Cataract surgery and vitrectomy patients