Study on the Relationship Between Periodontitis and Renal Disease

Zhejiang University

Status: Unknown

Conditions: Periodontitis

Study type: Observational

Funder types: Other

Identifiers

NCT02417363

ZJUSH2015-1

Details and patient eligibility

About

Analysis of inflammatory markers in periodontitis and patients with early and middle stage renal disease.

Full description

A total of 200 population is recruited, individuals are divided into four groups according to a periodontal examination and a general physical examination: healthy individuals ,periodontitis, renal disease patients with healthy periodontium, and renal disease patients wth peridontitis. Fasting blood samples and gingival crevicular fluid are collected from all individuals, and inflammatory markers are analysed for the four groups.

Enrollment: 200 estimated patients

Sex: All

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• all participants were in general good health(except renal disease) and non-smoking

Exclusion criteria

• less than 20 teeth in the dentin
• hypertension
• the presence of systemic disease (e.g., diabetes mellitus ,coronary heart disease, liver, or lung disease)
• a history or the symptom of any other acute or chronic infections
• systemic antibiotic treatment within previous 4 weeks
• periodontal treatment within1 month

Trial design

200 participants in 4 patient groups

Group A

Description:

the control group,healthy individuals

Group B

Description:

patients with 1-4 stage K/DOQI (Kidney Disease Outcome Quality Initiative) chronic kidney disease, but healthy periodontium

Group C

Description:

patients with periodontitis, but healthy renal conditions

Group D

Description:

patients with 1-4 stage K/DOQI (Kidney Disease Outcome Quality Initiative) chronic kidney disease and periodontitis