Study on Yangxue Nao Granules Reducing the Risk of Stroke

Peking University

Status

Completed

Conditions

Cerebral Infarction

Treatments

Drug: Raise serum brain granules

Drug: No nourishing serum brain granules are used

Study type

Observational

Funder types

Other

Identifiers

NCT04949906

M2019439

Details and patient eligibility

About

Objective: To explore the effectiveness of raising serum nao granules in reducing the risk of bleeding in patients with acute ischemic stroke treated with intravenous thrombolysis in the real world

Full description

Objective: To explore the effectiveness of raising serum nao granules in reducing the risk of bleeding in patients with acute ischemic stroke treated with intravenous thrombolysis in the real world Study Design. This study was a single center real world study. Through the review data, this study included in January 1, 2017 to September 30, 2019, see a doctor at Peking University third hospital neurology, emergency diagnosis of acute ischemic stroke, and venous thrombolysis in patients with a queue, on the basis of whether the application have serum brain particles are divided into a group and the control group, serum application parameters and nonparametric comparison, K-M curve and Cox regression model were used to evaluate the effectiveness of Yangxuenao granules in reducing bleeding conversion after intravenous thrombolysis by comparing the number of microbleeding, stroke severity score and modified Rankin score after 3 months follow-up with the weighted craniocerebral magnetic sensitivity imaging sequence reexamined within 48 hours.

Enrollment

150 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

A cohort of patients admitted to the Department of Emergency Neurology at Peking University Third Hospital on January 1, 2017 and admitted on September 30, 2019, who were diagnosed with acute ischemic stroke and underwent intravenous thrombolysis.

Exclusion criteria

Patients who underwent intravenous thrombolysis but were confirmed to be apoplexy
like by imaging and other clinical examinations; Incomplete craniocerebral MRI examination;
Bridging endovascular therapy;
The previous application of Yangxuenao granules or other drugs with similar effects;