Study the Role of Stem Cell in Curing Drug Induced Liver Injury in Metastatic Breast Cancer (MBC)

Peking University Cancer Hospital & Institute

Status: Completed

Conditions: Neoplasm Metastasis; Breast Neoplasms

Study type: Observational

Funder types: Other

Identifiers

NCT01231022

DILI

Details and patient eligibility

About

The investigators want to know the role of Peripheral hematopoietic stem cell infusion in avoiding Drug Induced Liver Injury,and also try to research SNPs genotyping associated with Drug Induced Liver Injury.

Full description

1. The researcher investigate the incidence and the cause of Drug Induced Liver Injury in MBC.
2. Patients having a complete clinical history and physical examination, receive routine chemotherapy.
3. Venous blood Sample(4 ml)is collected before and after each cycle according to the planning time.
4. Genomic DNA,RNA and upper serum is isolated. ELISA、rt-PCR or PCR-direct sequencing is used to detect the protein or gene expression associated with liver function.

Enrollment: 52 patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients should be histologically confirmed with metastatic breast cancer;
• an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2;
• Normal cardiac, hepatic, renal and bone marrow functions;
• Life expectancy ≥3 months;

Exclusion criteria

• previous history of other malignancies;
• Central nervous system metastases;
• Serious or uncontrolled concurrent medical illness.