Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow Allograft (LymphImaging)

Association Pour l'Aide a la Recherche en Immunologie Pediatrique

Status: Completed

Conditions: Severe Combined Immunodeficiency

Study type: Observational

Funder types: Other

Identifiers

NCT04246840

AARIP-01

Details and patient eligibility

About

To investigate the presence of seconday of lymphoid organs in patients who underwent allogenic hematopoietic stem cell transplantation 15 to 45 years ago.

The goal aims to assess the development of seconday lymphoid organs given the fact that the absence of myeloablation these patients present a split chimerism between T lymphocytes and the other leucocytes. Thus, they may not be able to generate seconday lymphoid organs. Practically, whole body MRI is being used to visualise and quantify both mediastinal and intraabdominal lymph nodes. Delta will be compared with those obtained in healthy age-matched individuals. It is scheduled to include 15 patients and 15 controls.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with SCID transplanted 15-45 years ago

Exclusion criteria

• None

Trial design

18 participants in 2 patient groups

Study group

Description:

15 adult patients who underwent allogenic hematopoietic stem cell transplantation (HSCT) for severe combined immunodeficieny 15 to 45 years ago

Control group

Description:

15 age-matched healthy individuals