Study to Assess Safety, Tolerability, and Pharmacokinetics of Oral Doses for AC430 in Healthy Subjects

Daiichi Sankyo

Status and phase

Completed

Phase 1

Conditions

Rheumatoid Arthritis

Treatments

Drug: AC430

Study type

Interventional

Funder types

Industry

Identifiers

NCT01287858

AC430-001

Details and patient eligibility

About

AC430 will be administered, orally under fasting conditions (fasting 4 hours before and 2 hours after dosing) with approximately 240 mL of water either once daily or twice daily. It is designed to assess the safety, tolerability, and pharmacokinetics of single and multiple oral doses of AC430.

Full description

A dose-finding study of AC430 in healthy volunteers.

Enrollment

88 patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Important Inclusion Criteria:

Healthy normal males and females, age 18 to 45, inclusive, at the time of consent
Able to communicate effectively in the English language
Able to provide valid, written informed consent
Able to swallow up to 20 capsules of study drug
BMI (body mass index) ranging between 18 and 30 kg/m2, inclusive
Minimum weight of 50 kg
Serum Creatinine ≤ ULN (upper limit of normal) and estimated creatinine clearance at screening of ≥ 80 mL/min per the Cockcroft-Gault equation
Total serum bilirubin ≤ ULN (may be repeated to confirm eligibility)
Serum aspartate transaminase (AST) and alanine transaminase (ALT) ≤ ULN (may be repeated to confirm eligibility)
Male subjects must either be sterile or agree to use from Check-in until 90 days following the last dose of AC430, an acceptable form of birth control.
Female participants must be either of non-child-bearing potential or agree to use an acceptable form of birth control.

Important Exclusion Criteria:

History of clinically significant drug allergy
Participation in another clinical trial with receipt of an Investigational Product within 90 days before dose administration (or 5 half-lives, whichever is longer)
Major surgery within 90 days before study enrollment
Use of prescription, over the counter, or herbal medications or supplements, including oral contraceptives within 14 days of check-in
A history of drug abuse or a history of alcohol abuse within 1 year prior to Screening
Current or recent (within 30 days before enrollment) use of tobacco or nicotine products
Consumption of alcohol containing beverages > an average of 14 drinks per week or unwillingness to refrain from ethanol consumption while confined to the study unit
Inadequate venous access that would interfere with obtaining blood samples
Recipients of blood transfusion or transfusion of blood or plasma products, within 90 days before study drug administration
Donation of blood ≥ 500 mL within 2 months before study drug administration
History or positive laboratory evidence of Human immunodeficiency virus (HIV), Hepatitis B antigen and antibody, or Hepatitis C, or history of Tuberculosis (TB) infection, or a positive result for Quantiferon Gold test
Prolonged average of the corrected QTc by Fridericia's correction factor (QTcF) interval on screening electrocardiogram (ECG) triplicate (≥ 450 ms for males and ≥ 470 ms for females)
Abnormal laboratory values that are considered clinically significant by the Investigator
History of cancer
History of eating disorders within the past 3 months
History of a seizure disorder or clinically significant head injury
Positive urine drug screen for drugs of abuse including alcohol
Active infection within 90 days of check-in
Medical condition, serious intercurrent illness, cardiovascular, pulmonary, neurologic, psychiatric, renal, hepatic or gastrointestinal disease, or other extenuating circumstance that, in the judgment of the Principal Investigator, could jeopardize subject safety or interfere with the objectives of the study