Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Palovarotene Ophthalmic Solution in Healthy Adult Subjects

Clementia Pharmaceuticals

Status and phase: Completed; Phase 1

Conditions: Dry Eye Disease

Treatments: Drug: Palovarotene; Drug: Vehicle

Study type: Interventional

Funder types: Industry

Identifiers

NCT04762355

PVO-3A-101

Details and patient eligibility

About

Dry eye disease (DED) is a keratoconjunctive disorder that "is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. The goal of this study is to assess the safety, tolerability, and pharmacokinetics (PK) of multiple ascending doses of palovarotene ophthalmic solution in healthy adult subjects.

Enrollment: 48 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Key Inclusion Criteria:

• Healthy, adult, male or female, 18 to 55 years of age, inclusive, at screening.
• Continuous non-smoker who had not used nicotine containing products for at least 3 months prior to the first dosing and throughout the study, based on subject self-reporting.
• Body mass index (BMI) ≥18.0 and ≤32.0 kg/m2 at screening.
• Medically healthy as deemed by the Investigator or delegate and determined by medical history, physical examination, vital signs, 12-lead ECGs, and clinical laboratory results obtained within 28 days before the start of the study.
• Tolerate topical administration to the eye.
• Best corrected visual acuity is equal or better than 70 Early Treatment Diabetic Retinopathy Study (ETDRS) letter score in both eyes.

Key Exclusion Criteria:

• Mentally or legally incapacitated or had significant emotional problems at the time of the screening visit or expected during the conduct of the study.

• History or presence of clinically significant medical (systemic or ophthalmic) or psychiatric condition or disease in the opinion of the Investigator or delegate.

• History of any illness that, in the opinion of the Investigator or delegate, might have confounded the results of the study or posed an additional risk to the subject by their participation in the study.

• History or presence of alcoholism or drug abuse within the past 18 months prior to the first dosing.

• History or presence of hypersensitivity or idiosyncratic reaction to the study drug, systemic retinoids such as isotretinoin or related compounds (e.g., topical tretinoins, vitamin A), fluorescein, or parabens or to the inactive ingredients in the study formulation.

• History of any ocular surgery or laser within the past 6 months prior to screening.

• History of herpes simplex keratitis.

• History or presence of:

  1. Any chronic eye disease other than refractive error, incipient cataract, strabismic amblyopia, or anisometropic amblyopia.
  2. Acute eye disease (such as infection, corneal abrasion, or allergy) within the past 6 months from screening.

• Any currently active ocular condition that required use of topical eye drops.

• Had an intraocular pressure >21 mmHg.

• If ophthalmological examination at screening or Day 1 predose revealed abnormalities of the cornea, evidence of ocular infection, inflammation (dry eyes, blepharitis, allergic conjunctivitis, iritis, and uveitis), advanced or moderately injected pterygium, keratitis, narrow anterior chamber angles, clinically significant Meibomian gland dysfunction, or any finding in either the anterior segment or posterior segment of the eye, that could have compromised the study as per Investigator or delegate discretion.

• Any macular integrity issues or optic nerve head (ONH) cupping/abnormality on retinal exam.

• Occurrence of active seasonal allergies including ocular allergies (e.g., annual hay fever).

• Needed to wear contact lenses during the study.

• Positive results at screening for human immunodeficiency virus, hepatitis B surface antigen, or hepatitis C virus.

• Unable to refrain from or anticipates the use of any drug, including prescription and non-prescription medications, herbal remedies, or vitamin supplements beginning 14 days prior to the first dosing and throughout the study, unless permitted by the Investigator or delegate.

• Any drugs known to be significant inhibitors and inducers of CYP3A4 enzymes, including St. John's Wort, for 30 days prior to the first dosing and throughout the study.

• Ocular medication of any kind (including artificial tears), antihistamines, anticholinergics, and/or oral/nasal steroids for 30 days prior to the first dosing and throughout the study.

• Isotretinoin or other systemic retinoids beginning 30 days or 5 half-lives, whichever was longer

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Quadruple Blind

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48 participants in 3 patient groups

Dose 1

Experimental group

Description:

Subjects were randomized in a 3:1 ratio to receive one dose regimen of either active treatment or placebo (vehicle). Advancement of the study from the once daily (QD) dosing regimen to the twice daily (BID) dosing regimen, and dose escalation to the next dose regimen

Treatment:

Drug: Palovarotene

Drug: Vehicle

Dose 2

Experimental group

Description:

Subjects were randomized in a 3:1 ratio to receive one dose regimen of either active treatment or placebo (vehicle). Advancement of the study from the once daily (QD) dosing regimen to the twice daily (BID) dosing regimen, and dose escalation to the next dose regimen

Treatment:

Drug: Palovarotene

Drug: Vehicle

Dose 3

Experimental group

Description:

Subjects were randomized in a 3:1 ratio to receive one dose regimen of either active treatment or placebo (vehicle). Advancement of the study from the once daily (QD) dosing regimen to the twice daily (BID) dosing regimen, and dose escalation to the next dose regimen

Treatment:

Drug: Palovarotene

Drug: Vehicle