Study to Compare Different Light Therapies (Narrowband Ultraviolet B vs PUVA) for Hand and Foot Skin Diseases.

Mayo Clinic

Status and phase: Terminated; Early Phase 1

Conditions: Psoriasis; Dermatitis

Treatments: Procedure: Topical Psoralen plus ultraviolet A (PUVA); Procedure: Narrowband Ultraviolet B (TL-01UVB) Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT00217009

2435-04

Details and patient eligibility

About

Hand and foot skin diseases, such as dermatitis and psoriasis, that do not respond to topical creams can be treated with ultraviolet light therapy. Topical psoralen plus ultraviolet A (PUVA) is commonly used to treat these conditions, but requires additional time for the hands and feet to soak in psoralens before the light treatment. Newer narrowband ultraviolet B (NBUVB) units have become available which allow for light treatment without soaking first. The purpose of this study is to determine if NBUVB is as effective as PUVA for hand and foot skin diseases.

Enrollment: 3 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Bilateral hand or foot skin disease (dermatitis, psoriasis, etc.) with symmetric distribution and severity.

Exclusion criteria

Age <18 years Pregnancy Liver disease Kidney disease History of skin cancer Phototherapy or systemic therapy for the skin condition in the preceding 3 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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3 participants in 2 patient groups

Narrowband Ultraviolet B (TL-01UVB) Therapy

Active Comparator group

Description:

treatments - 3x weekly for 15 months

Treatment:

Procedure: Narrowband Ultraviolet B (TL-01UVB) Therapy

Topical Psoralen plus ultraviolet A (PUVA)

Active Comparator group

Description:

Treatments - 3x weekly for 15 months

Treatment:

Procedure: Topical Psoralen plus ultraviolet A (PUVA)