Study to Evaluate Nosocomial Transmission of Influenza

NHS Trust

Status: Unknown

Conditions: Influenza

Study type: Observational

Funder types: Other

Identifiers

NCT00798421

REC 07/H0402/59

UHL10421

Details and patient eligibility

About

The purpose of this study is to investigate whether influenza can be reliably transmitted from children to susceptible contacts in a health care setting. The goal is to develop a transmission that can then be used to assess interventions to prevent transmission

Research objectives:

To develop a model to investigate the frequency of influenza transmission from an infected child to a susceptible health care worker

Research Hypotheses:

Influenza viruses can be transmitted from infected children to exposed health care workers

Full description

CHildren with influenza infection presenting to ED will be identified by RAT. Healthy healthcare worker subjects will expose themselves and perform specific activities with the child.

subjects will be followed by diary card, clinical symptom scores and virology swabs to assess frequency of transmission

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria:

• Infected Children

  • Age < 16 years
  • Parents or legal guardians willing to give informed written consent
  • Presenting with a febrile illness confirmed as influenza by near patient rapid antigen testing

• Healthy volunteers

  • Willing to give informed written consent

Exclusion criteria

• Children

  • No parents or legal guardians able to give informed consent

• Healthy volunteers

  • known allergy to oseltamivir or zanamivir
  • presence of underlying condition or concomitant therapy requiring dose alteration of oseltamivir (severe renal or hepatic failure; methotrexate and probenecid)
  • underlying immunosuppressive disorder
  • known galactose intolerance
  • underlying chronic medical condition known to increase risk of influenza-related complications (including asthma, chronic pulmonary airways disease, chronic cardiovascular disease, diabetes mellitus, chronic neurological disorder)
  • inability or contraindication to collection of nasal swabs
  • previous influenza vaccination within 2 years
  • current smoker
  • pregnancy

Trial design

50 participants in 1 patient group

Heathcare worker

Description:

health care worker exposed to patient with influenza