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Study to Evaluate Safety, PK, PD, Immunogenicity & Antitumor Activity of MSC-1 in Patients With Adv Solid Tumors

AstraZeneca logo

AstraZeneca

Status and phase

Completed
Phase 1

Conditions

Advanced Solid Tumors
Non Small Cell Lung Cancer
Ovarian Cancer
Pancreatic Cancer

Treatments

Biological: MSC-1

Study type

Interventional

Funder types

Industry

Identifiers

NCT03490669
MSC-1-101
2017-003320-79 (EudraCT Number)

Details and patient eligibility

About

This is a 2-part study to evaluate the safety and antitumor activity of MSC-1. MSC-1 is a first-in-class, humanized monoclonal antibody (IgG1) which binds to the immunosuppressive human cytokine Leukemia Inhibitory Factor (LIF), and is intended to treat adult patients with Advanced Solid Tumors.

In part 1, multiple dose levels of MSC-1 in patients with advanced solid tumors will be studied to determine the recommended dose for further evaluation of safety and efficacy in Part 2.

Full description

MSC-1 is a first-in-class, humanized monoclonal antibody (IgG1) which binds to the immunosuppressive human cytokine Leukemia Inhibitory Factor (LIF), and is intended to treat adult patients with advanced solid tumors. LIF is a pleiotropic cytokine involved in many physiological and pathological processes including the promotion of an immunosuppressive environment. In cancer, it is hypothesized that LIF expressing malignancies co-opt this activity, creating an immunosuppressive tumor microenvironment as well as promoting the activity of cancer-initiating cell(s) (CICs). LIF is highly expressed in a subset of tumors across multiple solid tumor types.

During dose escalation, patients with advanced solid tumors will be treated with MSC-1 with the primary objective of determining the safety and tolerability of MSC-1 and defining an appropriate dose for further evaluation in dose expansion. MSC-1 will be administered intravenously (IV) until disease progression, unmanageable toxicity, withdrawal of consent or study termination.

In dose expansion, up to 4 parallel cohorts of patients with LIF-High tumors (NSCLC, Ovarian Cancer, Pancreatic Cancer), and a cohort of mixed solid tumors (referred to as the "basket cohort"), may be treated at the recommended expansion dose to further characterize the safety, tolerability, PK, PD and anti-tumor activity of MSC-1.

Enrollment

41 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (All patients):

  • Confirmed Advanced Unresectable Solid Tumor
  • Measurable disease by RECIST 1.1 by CT or MRI
  • Documented disease progression on or following last line of therapy
  • Archival tumor sample for submission
  • ECOG performance status 0 or 1
  • Resolution of all acute, reversible toxic effects of prior therapy or surgical procedures to at least grade 1 (except alopecia and peripheral neuropathy to at least grade 2)
  • Adequate organ function
  • A limited number of patients enrolled in Dose Escalation may be required to agree to pre- and on-treatment tumor biopsies

Inclusion Criteria (Dose Expansion patients only)

  • LIF- High NSCLC, Ovarian Cancer, or Pancreatic Cancer for the tumor-specific cohorts or Advanced Solid Tumor for the basket cohort as assessed by tumor tissue evaluation by IHC
  • All patients enrolled in Dose Expansion must agree to undergo pre- and on-treatment tumor biopsies

Exclusion Criteria (All Patients):

  • Systemic anti-cancer therapy within 4 weeks or 5 half-lives prior to study entry
  • Previous or concurrent malignancy that could affect compliance with protocol or interpretation of results
  • Clinically significant, unstable cardiovascular or pulmonary disease as specified in detail in the study protocol
  • History of acquired or congenital immunodeficiency syndrome or receiving immunosuppressive therapy
  • Uncontrolled infections or serologically positive HIV or hepatitis B or C infection
  • Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase risk associated with study participation or interfere with interpretation of study results

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Sequential Assignment

Masking

None (Open label)

41 participants in 2 patient groups

Dose Escalation
Experimental group
Description:
Multiple dose levels of MSC-1 treatment once every 3 weeks
Treatment:
Biological: MSC-1
Dose Expansion
Experimental group
Description:
MSC-1 treatment at the recommended Phase 2 dose once every 3 weeks
Treatment:
Biological: MSC-1

Trial contacts and locations

7

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Data sourced from clinicaltrials.gov

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