Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDD (TERPSIS)

Neurocrine Biosciences

Status and phase: Completed; Phase 2

Conditions: Major Depressive Disorder; Anhedonia

Treatments: Drug: Placebo; Drug: NBI-1065846

Study type: Interventional

Funder types: Industry

Identifiers

NCT05165394

NBI-1065846-MDD2020

Details and patient eligibility

About

To evaluate the efficacy of NBI-1065846 compared with placebo on improving symptoms of anhedonia in participants with major depressive disorder (MDD).

Enrollment: 93 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Key Inclusion Criteria:

Participants must meet all of the following key inclusion criteria:

1. Completed written informed consent.

2. Aged 18 to 65 years, inclusive, at the time of informed consent.

3. Primary diagnosis of MDD.

4. Participants must meet one of the following criteria:

   • must have been taking ≥1 antidepressant medication(s) for ≥8 weeks prior to screening.
   • must have received ≥1 antidepressant medication(s) for ≥8 weeks in the current or most recent episode of depression.

5. Snaith Hamilton Pleasure Scale (SHAPS) score is ≥30 at screening and Day 1.

Key Exclusion Criteria:

Participants will be excluded from the study if they meet any of the following key criteria:

1. Any psychiatric disorder disallowed per protocol and electroconvulsive therapy (ECT) within 6 months prior to screening. Comorbid anxiety disorders are not exclusionary.
2. Have a significant risk of suicidal or violent behavior.
3. A history of seizure disorder, stroke, Alzheimer disease, Parkinson disease, multiple sclerosis, head injury associated with loss of consciousness for more than 15 minutes, or other neurodegenerative disorder.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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93 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Participant follows Placebo schedule (57 days)

Treatment:

Drug: Placebo

Antidepressant

Experimental group

Description:

Participant follows NBI-1065846 schedule (57 days)

Treatment:

Drug: NBI-1065846