Study to Evaluate the Use of Ultrasound in the Diagnosis of Hemophilic Joint Disease

New York Presbyterian Hospital

Status: Completed

Conditions: Inherited Bleeding Disorders

Treatments: Procedure: MRI; Procedure: Power Doppler Sonography

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00212485

PDS

Details and patient eligibility

About

The purpose of this study is to see whether power Doppler sonography (PDS) can be used to diagnose synovitis in patients with inherited bleeding disorders.

Full description

Aim #1 - To determine if PDS can be used to diagnose synovial hypertrophy and inflammation in joint disease associated with inherited bleeding disorders. MRI will be used as a reference standard.

Aim #2 - To determine if PDS can be used to assess therapeutic response to treatment.

Aim #3 - To determine if PDS can be used as a screening tool for diagnosing early synovitis.

Enrollment: 43 patients

Sex: All

Ages: 1 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of inherited bleeding disorder

For Aim 1:

• Age of at least 6 years
• History of at least 4 bleeds in the same joint in the preceding 6 months
• Joint swelling, synovitis or deformity

For Aim 2:

• Meet inclusion criteria for Aim 1 and will be having a synovectomy

For Aim 3:

• Age of at least 1 year
• Have had at least 2 joint bleeds

Exclusion criteria

• Not meeting inclusion criteria

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)