Study to Gather Information About the Use of Healthcare Services and the Way the Disease is Cared for in Canadian Patients With Prostate Gland Cancer Which Spread Throughout the Body (REACTIVATE)

Bayer

Status: Completed

Conditions: Prostate Cancer

Treatments: Drug: Radium-223 dichloride (Xofigo, BAY88-8223)

Study type: Observational

Funder types: Industry

Identifiers

NCT04281147

20949

Details and patient eligibility

About

Study to gather information about the optimal placement of Ra-223 in the order of different treatments in terms of the effect on patients and in terms of the use of healthcare services for the treatment of Canadian patients with prostate gland cancer which spread to other parts of the body. In order to collect this information real world data from prostate gland cancer patients from four Canadian administrative databases will be analyzed.

Data collected from patients treated with their 2nd line of life-prolonging therapy for Non-Metastatic Castration Resistant Prostate Cancer (mCRPC) initiated from 01 Jan 2012 to 31 Dec 2017. For patients included in the study, all available data from the beginning for their record until death, lost to follow-up or database cut-off will be included. The index date is the date of initiation of the 2nd line life-prolonging therapy for mCRPC.

Enrollment: 4,301 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

• Use of at least 2 lines of life-prolonging mCRPC therapy
• The 2nd line of life-prolonging therapy was initiated between 01-Jan-2012 to 31-Dec-2017

Exclusion criteria

• No formal exclusion criteria will be applied in order to capture real world use of Ra-223

Trial design

4,301 participants in 3 patient groups

No Ra-223 received

Description:

Patients did not receive Ra-223

Early Ra-223 (2nd line)

Description:

Patients received Ra-223 in 2nd line

Treatment:

Drug: Radium-223 dichloride (Xofigo, BAY88-8223)

Late Ra-223 (3rd or later lines)

Description:

Patients received Ra-223 in 3rd or later lines

Treatment:

Drug: Radium-223 dichloride (Xofigo, BAY88-8223)