Study Using Genomic, Histologic and Radiomic Analysis to Evaluate Regional Tumor Heterogeneity in Patients Undergoing Surgery for Newly Diagnosed Glioblastoma

University of Michigan Rogel Cancer Center

Status: Terminated

Conditions: Glioblastoma

Treatments: Other: Tumor Biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT03287063

HUM00134165 (Other Identifier)

UMCC 2017.094

Details and patient eligibility

About

Glioblastomas (GBM) demonstrate in vivo genetic and histologic heterogeneity that can be non-invasively identified using imaging phenotypes that identify regionally distinct areas of tumor with genetic alterations that drive tumor resistance pathways. The researchers propose a unique approach to assess initial GBM heterogeneity by performing histological and genomic analysis of biopsies targeted by advanced MRI before treatment.

Enrollment: 6 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Suspected newly diagnosed or recurrent supratentorial glioblastoma eligible for surgical biopsy and/or resection
• Patients must be 18 years of age or older
• Study-specific informed consent approved for this purpose by the IRB of the University of Michigan

Exclusion criteria

• Patients unable to undergo MRI