Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors

Children's Oncology Group

Status: Completed

Conditions: Kidney Cancer

Treatments: Genetic: polymerase chain reaction; Genetic: protein expression analysis; Genetic: gene expression analysis; Genetic: DNA analysis; Other: laboratory biomarker analysis; Genetic: gene mapping; Other: medical chart review; Genetic: fluorescence in situ hybridization; Genetic: microarray analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01544569

AREN12B3 (Other Identifier)

CDR0000727229 (Other Identifier)

NCI-2012-00689 (Registry Identifier)

COG-AREN12B3 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer.

PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.

Full description

OBJECTIVES:

• To investigate the expression and function of transposons in 50 primary rhabdoid tumors.

OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.

Enrollment: 50 estimated patients

Sex: All

Ages: Under 1 year old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Freshly frozen rhabdoid tumors from either renal or extra-renal sites from children younger than 2 years of age
• Clinical patient information (age, gender, comorbidities, tumor stage, size, pathology, therapy, outcome) available

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified