Studying Biomarkers in Samples From Younger Patients With Wilms Tumor

Children's Oncology Group

Status

Completed

Conditions

Kidney Cancer

Treatments

Other: laboratory biomarker analysis

Procedure: spectroscopy

Genetic: gene expression analysis

Genetic: western blotting

Genetic: proteomic profiling

Genetic: reverse transcriptase-polymerase chain reaction

Other: immunohistochemistry staining method

Study type

Observational

Funder types

NETWORK

NIH

Identifiers

NCT01542333

AREN12B2 (Other Identifier)

COG-AREN12B2 (Other Identifier)

CDR0000726713 (Other Identifier)

NCI-2012-00686 (Registry Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tissue and urine from patients with cancer in the laboratory may help doctor learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in samples from younger patients with Wilms tumor.

Full description

OBJECTIVES:

To determine a unique molecular "finger print" of primary Wilms tumor arising in ethnically diverse children who are at increased risk to develop this lethal malignancy and subsequently relapse.
To determine a unique protein "finger print" from the urine of ethnically diverse children who develop Wilms tumor and subsequent relapse.

OUTLINE: Formalin-fixed paraffin-embedded and snap-frozen primary tissue samples, and urine samples collected at the time of diagnosis and before treatment, are analyzed for molecular and protein profile by MALDI-TOF mass spectroscopy, western blotting, immunohistochemistry, and reverse-transcriptase polymerase chain reaction (RT-PCR) assays.

Enrollment

20 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS: