Studying Gene Expression and Location in Samples From Patients With Brain Tumors

Children's Oncology Group

Status: Completed

Conditions: Brain and Central Nervous System Tumors

Treatments: Genetic: genetic linkage analysis; Genetic: gene expression analysis; Genetic: microarray analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT01585389

COG-ABTR12B3 (Other Identifier)

ABTR12B3 (Other Identifier)

CDR0000732178 (Other Identifier)

NCI-2012-00731 (Registry Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to brain tumors.

PURPOSE: This research studies gene expression and location in samples from patients with brain tumors.

Full description

OBJECTIVES:

• To determine the expression and subcellular localization of nei endonuclease VIII-like 3 (NEIL3) in brain tumors.

OUTLINE: Tissue microarray samples are analyzed for NEIL3 expression and subcellular localization by immunohistochemical methods.

Enrollment: 10 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Tissue microarrays (TMA) samples from the Biopathology Core

• Samples from patients diagnosed with brain tumors

  • Progenitor, or blast, cell origin

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified