Studying Genes, Environment, and Prostate Cancer Risk in Patients With or Without Prostate Cancer

Portland VA Medical Center

Status

Completed

Conditions

Hereditary Prostate Cancer

Prostate Cancer

Treatments

Other: medical chart review

Other: questionnaire administration

Other: laboratory biomarker analysis

Genetic: polymorphism analysis

Procedure: study of high risk factors

Genetic: DNA analysis

Procedure: evaluation of cancer risk factors

Study type

Observational

Funder types

Other U.S. Federal agency

Identifiers

NCT01013129

VAMC-OR-M1736

CDR0000648179

CPC-07129-L

Details and patient eligibility

About

RATIONALE: Gathering information about genetic and environmental factors may help doctors learn more about a person's risk for developing prostate cancer.

PURPOSE: This research project is studying genes, environment, and prostate cancer risk in patients with or without prostate cancer.

Full description

OBJECTIVES:

To determine the association between variation in genes involved in ROS detoxification, oxidative stress response, and prostate cancer risk.
To determine the association between fatty acid levels and prostate cancer risk.

OUTLINE: Probands undergo blood and saliva sample collection for fatty acid, DNA, and polymorphism analyses. Archived blood and tissue samples from probands who previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study are also analyzed. Medical records of probands are reviewed for demographics, history and course of disease, and clinical laboratory test results.

All probands completed the "Genetic Risk Easy Assessment Tool Family History of Cancer" and "Diet History and Environmental Risk Factor" questionnaires at baseline. If a proband previously participated on our Diet and Prostate Cancer Risk study, he was asked to complete the "Changes in Diet, Prescriptions, Supplementals and Herbal Remedies" questionnaire in addition to the "Genetic Risk Easy Assessment Tool Family History of Cancer" questionnaire at baseline for this study.

PROJECTED ACCRUAL: A total of 750 participants will be accrued for this study.

Enrollment

748 patients

Sex

Male

Ages

21 to 120 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Meets 1 of the following criteria:
- Prior diagnosis of prostate cancer or negative prostate biopsy AND previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study and consented to future studies (proband)
- Referred to the Portland VA Medical Center urology clinic for a prostate biopsy (proband)
  - Introduced to this study by a proband OR found to be related to a proband who is part of a homogenous high-risk subgroup after completion of the family history of cancer analysis

PATIENT CHARACTERISTICS: